@article {678936,
	title = {Thermotaxis navigation behavior},
	journal = {WormBook : the online review of C. elegans biology},
	year = {2014},
	pages = {1-10},
	abstract = {This chapter describes four different protocols used to assay thermotaxis navigation behavior of single, or populations of, C. elegans hermaphrodites on spatial thermal gradients within the physiological temperature range (15-25{\textdegree}C). A method to assay avoidance of noxious temperatures is also described.},
	url = {http://www.wormbook.org/chapters/www_thermonav/thermonav.html},
	author = {Miriam B. Goodman and Mason Klein and Samuel Lasse and Linjiao Luo and Ikue Mori and Aravi Samuel and Piali Sengupta and Wang, Dong}
}
@article {144606,
	title = {Bidirectional thermotaxis in Caenorhabditis elegans is mediated by distinct sensorimotor strategies driven by the AFD thermosensory neurons},
	journal = {Proceedings of the National Academy of Sciences USA},
	volume = {111},
	year = {2014},
	pages = {2776-2781},
	abstract = {The nematode Caenorhabditis elegans navigates toward a pre- ferred temperature setpoint (Ts) determined by long-term temper- ature exposure. During thermotaxis, the worm migrates down temperature gradients at temperatures above Ts (negative ther- motaxis) and performs isothermal tracking near Ts. Under some conditions, the worm migrates up temperature gradients below Ts (positive thermotaxis). Here, we analyze positive and negative thermotaxis toward Ts to study the role of specific neurons that have been proposed to be involved in thermotaxis using genetic ablation, behavioral tracking, and calcium imaging. We find differ- ences in the strategies for positive and negative thermotaxis. Neg- ative thermotaxis is achieved through biasing the frequency of reorientation maneuvers (turns and reversal turns) and biasing the direction of reorientation maneuvers toward colder temper- atures. Positive thermotaxis, in contrast, biases only the direction of reorientation maneuvers toward warmer temperatures. We find that the AFD thermosensory neuron drives both positive and negative thermotaxis. The AIY interneuron, which is postsyn- aptic to AFD, may mediate the switch from negative to positive thermotaxis below Ts. We propose that multiple thermotactic behaviors, each defined by a distinct set of sensorimotor trans- formations, emanate from the AFD thermosensory neurons. AFD learns and stores the memory of preferred temperatures, detects temperature gradients, and drives the appropriate thermotactic behavior in each temperature regime by the flexible use of downstream circuits.},
	url = {https://www.pnas.org/content/111/7/2776},
	author = {Linjiao Luo and Nathan Cook and Vivek Venkatachalam and Luis Martinez-Velazquez and Xiaodong Zhang and Ana Calvo and Josh Hawk and Bronwyn MacInnis and Michelle Frank and Jia Hong Ray Ng and Mason Klein and Marc Gershow and Marc Hammarlund and Miriam Goodman and Daniel Colon-Ramos and Zhang,Yun and Aravinthan D T Samuel}
}
@article {164126,
	title = {Dynamic encoding of perception, memory and movement in a C. elegans chemotaxis circuit},
	journal = {Neuron},
	volume = {82},
	year = {2014},
	pages = {1115-1128},
	abstract = {Brain circuits endow behavioral flexibility. Here, we study circuits encoding flexible 26 chemotaxis in C. elegans, where the animal navigates up or down NaCl gradients (positive or negative chemotaxis) to reach the salt concentration of previous growth (the setpoint). The ASER sensory neuron mediates positive and negative chemotaxis by regulating the frequency and direction of reorientation movements in response to salt gradients. Both salt gradients and setpoint memory are encoded in ASER temporal activity patterns. Distinct temporal activity patterns in interneurons immediately downstream of ASER encode chemotactic movement decisions. Different interneuron combinations regulate positive vs. negative chemotaxis. We conclude that sensorimotor pathways are segregated immediately after the primary sensory neuron in the chemotaxis circuit, and sensory representation is rapidly transformed to motor representation at the first interneuron layer. Our study reveals compact encoding of perception, memory, and locomotion in an experience dependent navigational behavior in C. elegans.},
	url = {https://linkinghub.elsevier.com/retrieve/pii/S0896627314003961},
	author = {Linjiao Luo and Quan Wen and Jing Ren and Hendricks,Michael and Marc Gershow and Qin,Yuqi and Joel Greenwood and Edward Soucy and Mason Klein and Heidi Smith-Parker and Ana Calvo and Daniel Colon-Ramos and Samuel,Aravinthan and Zhang,Yun}
}
