@article {Witvliet2020.04.30.066209,
	title = {Connectomes across development reveal principles of brain maturation},
	journal = {Nature},
	volume = {596},
	year = {2021},
	pages = {257{\textendash}261},
	publisher = {Cold Spring Harbor Laboratory},
	abstract = {From birth to adulthood, an animal{\textquoteright}s nervous system changes as its body grows and its behaviours mature. The form and extent of circuit remodelling across the connectome is unknown. We used serial-section electron microscopy to reconstruct the full brain of eight isogenic C. elegans individuals across postnatal stages to learn how it changes with age. The overall geometry of the brain is preserved from birth to adulthood. Upon this constant scaffold, substantial changes in chemical synaptic connectivity emerge. Comparing connectomes among individuals reveals substantial connectivity differences that make each brain partly unique. Comparing connectomes across maturation reveals consistent wiring changes between different neurons. These changes alter the strength of existing connections and create new connections. Collective changes in the network alter information processing. Over development, the central decision-making circuitry is maintained whereas sensory and motor pathways substantially remodel. With age, the brain progressively becomes more feedforward and discernibly modular. Developmental connectomics reveals principles that underlie brain maturation.Competing Interest StatementThe authors have declared no competing interest.},
	doi = {10.1101/2020.04.30.066209},
	url = {https://www.nature.com/articles/s41586-021-03778-8},
	author = {Witvliet, Daniel and Ben Mulcahy and Mitchell, James K. and Meirovitch, Yaron and Berger, Daniel R. and Wu, Yuelong and Liu, Yufang and Koh, Wan Xian and Parvathala, Rajeev and Douglas Holmyard and Schalek, Richard L. and Shavit, Nir and Chisholm, Andrew D. and Lichtman, Jeff W. and Aravinthan D. T. Samuel and Mei Zhen}
}
