@article {483551,
	title = {Neuroendocrine Modulation Sustains the C. elegans Forward Motor State},
	journal = {eLIFE},
	volume = {5},
	year = {2016},
	month = {18 Nov},
	pages = {e19887},
	abstract = {Neuromodulators shape neural circuit dynamics. Combining electron microscopy, genetics, transcriptome profiling, calcium imaging, and optogenetics, we discovered a peptidergic neuron that modulates\&nbsp;C. elegans\&nbsp;motor circuit dynamics. The Six/SO-family homeobox transcription factor UNC-39 governs lineage-specific neurogenesis to give rise to a neuron RID. RID bears the anatomic hallmarks of a specialized endocrine neuron: it harbors near-exclusive dense core vesicles that cluster periodically along the axon, and expresses multiple neuropeptides, including the FMRF-amide-related FLP-14. RID activity increases during forward movement. Ablating RID reduces the sustainability of forward movement, a phenotype partially recapitulated by removing FLP-14. Optogenetic depolarization of RID prolongs forward movement, an effect reduced in the absence of FLP-14. Together, these results establish the role of a neuroendocrine cell RID in sustaining a specific behavioral state in\&nbsp;C. elegans.},
	url = {https://elifesciences.org/content/5/e19887},
	author = {Maria A Lim and Jyothsna Chitturi and Valeriya Laskova and Jun Meng and Daniel Findeis and Anne Wiekenberg and Ben Mulcahy and Linjiao Luo and Yan Li and Yangning Lu and Wesley Hung and Yixin Qu and Chi-Yip Ho and Douglas Holmyard and Ni Ji and Rebecca McWhirter and Aravinthan D T Samuel and David M Miller and Ralf Schnabel and John A Calarco and Mei Zhen}
}
